Sending sisters their separate ways

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Sending sisters their separate ways

S ister chromatids are often reluctant to separate during mitosis. Germann et al. show that a protein involved in DNA replication and repair helps eliminate lingering connections that can hold sister chromatids together (1). Sister chromatids tangle almost every time a cell enters mitosis. Unless the cell releases these links, the structures can break or fail to separate properly. Two kinds of ...

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C hromosomes are highly organized in the cell, yet they undergo dynamic conformational changes throughout the cell cycle. Such conformational changes become crucial, particularly when duplicated chromosomes (sister chromatids) separate from each other before cell division. From a mechanistic point of view, two fundamental processes must operate for successful separation of chromosomes. One is p...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2013

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb.2041if